Cart
sales@molnova.com
AY 77
CAS No. 1835734-92-3
AY 77( —— )
Catalog No. M35259 CAS No. 1835734-92-3
AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 1043 | Get Quote |
|
| 5MG | 1406 | Get Quote |
|
| 10MG | 1891 | Get Quote |
|
| 25MG | 2723 | Get Quote |
|
| 50MG | 3671 | Get Quote |
|
| 100MG | 4851 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAY 77
-
NoteResearch use only, not for human use.
-
Brief DescriptionAY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM).
-
DescriptionAY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetPAR
-
RecptorProtease-activated Receptor | Calcium Channel | ERK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1835734-92-3
-
Formula Weight404.5
-
Molecular FormulaC21H32N4O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES[C@H](CC1CCCCC1)(C(N[C@H](C(N)=O)[C@@H]2CCCCC2)=O)NC(=O)C3=CC=NO3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kl?sel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323.?
molnova catalog
related products
-
I-191
I-191 is a potent antagonist of protease-activated receptor 2 (PAR2)?inhibits multiple signaling functions in human cancer cells.?
-
iso-TRAP-6
iso-TRAP-6 (iso-SFLLRN), a hexapeptide derived from the substitution of isoserine for serine, is a protease-activated receptor 1 (PAR1) agonist that activates platelets via PAR-1.
-
PAR-4 Agonist Peptid...
PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.
